serum il 6 levels Search Results


postoperative serum interleukin-6 level  (Hasegawa Co Ltd)
90
Hasegawa Co Ltd postoperative serum interleukin-6 level
Postoperative Serum Interleukin 6 Level, supplied by Hasegawa Co Ltd, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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serum levels of tnf-α, il-6, and mcp-1  (srl inc)
90
srl inc serum levels of tnf-α, il-6, and mcp-1
Serum Levels Of Tnf α, Il 6, And Mcp 1, supplied by srl inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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serum il-6 levels  (Cayman Chemical)
90
Cayman Chemical serum il-6 levels
Sunitinib altered the liver metabolome. Principle component analysis (PCA) score plot (a) and scatter plot (b) derived from ultra‐performance LC electrospray ionization quadrupole time‐of‐flight MS data of liver ions. Each point represented an individual mouse liver sample (top) and an ion in the sample (bottom). Metabolites were labelled in the loading plot, which included three xenobiotic metabolites and seven endogenous metabolites. (c) Heatmap of 55 significantly changed endogenous metabolites (P < 0.05) in liver. (d) Correlation analysis between 55 changed endogenous metabolites and serum alkaline phosphatase (ALP) and hepatic Il1b <t>and</t> <t>Il6</t> mRNAs. All these metabolites showed a good correlation with serum ALP and hepatic Il1b, and Il6 mRNAs. (e) Real‐time PCR analysis was performed to measure the levels of mRNA‐encoding enzymes associated with fatty acid synthesis and metabolism. Acylcarnitine‐related genes were significantly inhibited after sunitinib treatment. (f) Real‐time PCR analysis of the hepatic mRNAs associated with bile acid synthesis and transport. Bile acid‐related genes were significantly inhibited after sunitinib treatment. Values represented fold change after normalization to control. All data plotted are means ± SEM (n = 5). *P < 0.05 significantly different from control. CA, cholic acid; Ile, isoleucine; Leu, leucine; LCA, lithocholic acid; LPC, lyso‐phosphocholine; LPE, lyso‐phosphatidylethanolamine; TCA, taurocholic acid; TDCA, taurodeoxycholic acid; TUDCA, tauroursodeoxycholic acid; TαMCA, tauro‐α‐muricholic acid; TβMCA, tauro‐β‐muricholic acid
Serum Il 6 Levels, supplied by Cayman Chemical, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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serum il-6 levels - by Bioz Stars, 2026-03
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enzymelinked immunosorbent assay (elisa) mouse il6 serum levels  (ImmunoTools)
90
ImmunoTools enzymelinked immunosorbent assay (elisa) mouse il6 serum levels
Sunitinib altered the liver metabolome. Principle component analysis (PCA) score plot (a) and scatter plot (b) derived from ultra‐performance LC electrospray ionization quadrupole time‐of‐flight MS data of liver ions. Each point represented an individual mouse liver sample (top) and an ion in the sample (bottom). Metabolites were labelled in the loading plot, which included three xenobiotic metabolites and seven endogenous metabolites. (c) Heatmap of 55 significantly changed endogenous metabolites (P < 0.05) in liver. (d) Correlation analysis between 55 changed endogenous metabolites and serum alkaline phosphatase (ALP) and hepatic Il1b <t>and</t> <t>Il6</t> mRNAs. All these metabolites showed a good correlation with serum ALP and hepatic Il1b, and Il6 mRNAs. (e) Real‐time PCR analysis was performed to measure the levels of mRNA‐encoding enzymes associated with fatty acid synthesis and metabolism. Acylcarnitine‐related genes were significantly inhibited after sunitinib treatment. (f) Real‐time PCR analysis of the hepatic mRNAs associated with bile acid synthesis and transport. Bile acid‐related genes were significantly inhibited after sunitinib treatment. Values represented fold change after normalization to control. All data plotted are means ± SEM (n = 5). *P < 0.05 significantly different from control. CA, cholic acid; Ile, isoleucine; Leu, leucine; LCA, lithocholic acid; LPC, lyso‐phosphocholine; LPE, lyso‐phosphatidylethanolamine; TCA, taurocholic acid; TDCA, taurodeoxycholic acid; TUDCA, tauroursodeoxycholic acid; TαMCA, tauro‐α‐muricholic acid; TβMCA, tauro‐β‐muricholic acid
Enzymelinked Immunosorbent Assay (Elisa) Mouse Il6 Serum Levels, supplied by ImmunoTools, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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serum relative il-6 level  (SomaLogic)
90
SomaLogic serum relative il-6 level
Sunitinib altered the liver metabolome. Principle component analysis (PCA) score plot (a) and scatter plot (b) derived from ultra‐performance LC electrospray ionization quadrupole time‐of‐flight MS data of liver ions. Each point represented an individual mouse liver sample (top) and an ion in the sample (bottom). Metabolites were labelled in the loading plot, which included three xenobiotic metabolites and seven endogenous metabolites. (c) Heatmap of 55 significantly changed endogenous metabolites (P < 0.05) in liver. (d) Correlation analysis between 55 changed endogenous metabolites and serum alkaline phosphatase (ALP) and hepatic Il1b <t>and</t> <t>Il6</t> mRNAs. All these metabolites showed a good correlation with serum ALP and hepatic Il1b, and Il6 mRNAs. (e) Real‐time PCR analysis was performed to measure the levels of mRNA‐encoding enzymes associated with fatty acid synthesis and metabolism. Acylcarnitine‐related genes were significantly inhibited after sunitinib treatment. (f) Real‐time PCR analysis of the hepatic mRNAs associated with bile acid synthesis and transport. Bile acid‐related genes were significantly inhibited after sunitinib treatment. Values represented fold change after normalization to control. All data plotted are means ± SEM (n = 5). *P < 0.05 significantly different from control. CA, cholic acid; Ile, isoleucine; Leu, leucine; LCA, lithocholic acid; LPC, lyso‐phosphocholine; LPE, lyso‐phosphatidylethanolamine; TCA, taurocholic acid; TDCA, taurodeoxycholic acid; TUDCA, tauroursodeoxycholic acid; TαMCA, tauro‐α‐muricholic acid; TβMCA, tauro‐β‐muricholic acid
Serum Relative Il 6 Level, supplied by SomaLogic, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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serum relative il-6 level - by Bioz Stars, 2026-03
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serum il6 levels  (Bioscientifica Ltd)
90
Bioscientifica Ltd serum il6 levels
Sunitinib altered the liver metabolome. Principle component analysis (PCA) score plot (a) and scatter plot (b) derived from ultra‐performance LC electrospray ionization quadrupole time‐of‐flight MS data of liver ions. Each point represented an individual mouse liver sample (top) and an ion in the sample (bottom). Metabolites were labelled in the loading plot, which included three xenobiotic metabolites and seven endogenous metabolites. (c) Heatmap of 55 significantly changed endogenous metabolites (P < 0.05) in liver. (d) Correlation analysis between 55 changed endogenous metabolites and serum alkaline phosphatase (ALP) and hepatic Il1b <t>and</t> <t>Il6</t> mRNAs. All these metabolites showed a good correlation with serum ALP and hepatic Il1b, and Il6 mRNAs. (e) Real‐time PCR analysis was performed to measure the levels of mRNA‐encoding enzymes associated with fatty acid synthesis and metabolism. Acylcarnitine‐related genes were significantly inhibited after sunitinib treatment. (f) Real‐time PCR analysis of the hepatic mRNAs associated with bile acid synthesis and transport. Bile acid‐related genes were significantly inhibited after sunitinib treatment. Values represented fold change after normalization to control. All data plotted are means ± SEM (n = 5). *P < 0.05 significantly different from control. CA, cholic acid; Ile, isoleucine; Leu, leucine; LCA, lithocholic acid; LPC, lyso‐phosphocholine; LPE, lyso‐phosphatidylethanolamine; TCA, taurocholic acid; TDCA, taurodeoxycholic acid; TUDCA, tauroursodeoxycholic acid; TαMCA, tauro‐α‐muricholic acid; TβMCA, tauro‐β‐muricholic acid
Serum Il6 Levels, supplied by Bioscientifica Ltd, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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serum il6 levels - by Bioz Stars, 2026-03
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ifn-β, il-6, and tnf-α levels in mouse serum and peritoneal lavage fluid  (Dakewe Biotech Co)
90
Dakewe Biotech Co ifn-β, il-6, and tnf-α levels in mouse serum and peritoneal lavage fluid
Sunitinib altered the liver metabolome. Principle component analysis (PCA) score plot (a) and scatter plot (b) derived from ultra‐performance LC electrospray ionization quadrupole time‐of‐flight MS data of liver ions. Each point represented an individual mouse liver sample (top) and an ion in the sample (bottom). Metabolites were labelled in the loading plot, which included three xenobiotic metabolites and seven endogenous metabolites. (c) Heatmap of 55 significantly changed endogenous metabolites (P < 0.05) in liver. (d) Correlation analysis between 55 changed endogenous metabolites and serum alkaline phosphatase (ALP) and hepatic Il1b <t>and</t> <t>Il6</t> mRNAs. All these metabolites showed a good correlation with serum ALP and hepatic Il1b, and Il6 mRNAs. (e) Real‐time PCR analysis was performed to measure the levels of mRNA‐encoding enzymes associated with fatty acid synthesis and metabolism. Acylcarnitine‐related genes were significantly inhibited after sunitinib treatment. (f) Real‐time PCR analysis of the hepatic mRNAs associated with bile acid synthesis and transport. Bile acid‐related genes were significantly inhibited after sunitinib treatment. Values represented fold change after normalization to control. All data plotted are means ± SEM (n = 5). *P < 0.05 significantly different from control. CA, cholic acid; Ile, isoleucine; Leu, leucine; LCA, lithocholic acid; LPC, lyso‐phosphocholine; LPE, lyso‐phosphatidylethanolamine; TCA, taurocholic acid; TDCA, taurodeoxycholic acid; TUDCA, tauroursodeoxycholic acid; TαMCA, tauro‐α‐muricholic acid; TβMCA, tauro‐β‐muricholic acid
Ifn β, Il 6, And Tnf α Levels In Mouse Serum And Peritoneal Lavage Fluid, supplied by Dakewe Biotech Co, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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ifn-β, il-6, and tnf-α levels in mouse serum and peritoneal lavage fluid - by Bioz Stars, 2026-03
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serum tnf-α, il-6, lps, insulin and adiponectin protein 171 levels  (Cloud-Clone corp)
90
Cloud-Clone corp serum tnf-α, il-6, lps, insulin and adiponectin protein 171 levels
Sunitinib altered the liver metabolome. Principle component analysis (PCA) score plot (a) and scatter plot (b) derived from ultra‐performance LC electrospray ionization quadrupole time‐of‐flight MS data of liver ions. Each point represented an individual mouse liver sample (top) and an ion in the sample (bottom). Metabolites were labelled in the loading plot, which included three xenobiotic metabolites and seven endogenous metabolites. (c) Heatmap of 55 significantly changed endogenous metabolites (P < 0.05) in liver. (d) Correlation analysis between 55 changed endogenous metabolites and serum alkaline phosphatase (ALP) and hepatic Il1b <t>and</t> <t>Il6</t> mRNAs. All these metabolites showed a good correlation with serum ALP and hepatic Il1b, and Il6 mRNAs. (e) Real‐time PCR analysis was performed to measure the levels of mRNA‐encoding enzymes associated with fatty acid synthesis and metabolism. Acylcarnitine‐related genes were significantly inhibited after sunitinib treatment. (f) Real‐time PCR analysis of the hepatic mRNAs associated with bile acid synthesis and transport. Bile acid‐related genes were significantly inhibited after sunitinib treatment. Values represented fold change after normalization to control. All data plotted are means ± SEM (n = 5). *P < 0.05 significantly different from control. CA, cholic acid; Ile, isoleucine; Leu, leucine; LCA, lithocholic acid; LPC, lyso‐phosphocholine; LPE, lyso‐phosphatidylethanolamine; TCA, taurocholic acid; TDCA, taurodeoxycholic acid; TUDCA, tauroursodeoxycholic acid; TαMCA, tauro‐α‐muricholic acid; TβMCA, tauro‐β‐muricholic acid
Serum Tnf α, Il 6, Lps, Insulin And Adiponectin Protein 171 Levels, supplied by Cloud-Clone corp, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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serum tnf-α, il-6, lps, insulin and adiponectin protein 171 levels - by Bioz Stars, 2026-03
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serum levels of il6  (Koma Biotech)
90
Koma Biotech serum levels of il6
Sunitinib altered the liver metabolome. Principle component analysis (PCA) score plot (a) and scatter plot (b) derived from ultra‐performance LC electrospray ionization quadrupole time‐of‐flight MS data of liver ions. Each point represented an individual mouse liver sample (top) and an ion in the sample (bottom). Metabolites were labelled in the loading plot, which included three xenobiotic metabolites and seven endogenous metabolites. (c) Heatmap of 55 significantly changed endogenous metabolites (P < 0.05) in liver. (d) Correlation analysis between 55 changed endogenous metabolites and serum alkaline phosphatase (ALP) and hepatic Il1b <t>and</t> <t>Il6</t> mRNAs. All these metabolites showed a good correlation with serum ALP and hepatic Il1b, and Il6 mRNAs. (e) Real‐time PCR analysis was performed to measure the levels of mRNA‐encoding enzymes associated with fatty acid synthesis and metabolism. Acylcarnitine‐related genes were significantly inhibited after sunitinib treatment. (f) Real‐time PCR analysis of the hepatic mRNAs associated with bile acid synthesis and transport. Bile acid‐related genes were significantly inhibited after sunitinib treatment. Values represented fold change after normalization to control. All data plotted are means ± SEM (n = 5). *P < 0.05 significantly different from control. CA, cholic acid; Ile, isoleucine; Leu, leucine; LCA, lithocholic acid; LPC, lyso‐phosphocholine; LPE, lyso‐phosphatidylethanolamine; TCA, taurocholic acid; TDCA, taurodeoxycholic acid; TUDCA, tauroursodeoxycholic acid; TαMCA, tauro‐α‐muricholic acid; TβMCA, tauro‐β‐muricholic acid
Serum Levels Of Il6, supplied by Koma Biotech, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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serum levels of il6 - by Bioz Stars, 2026-03
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serum il-6 level testing  (Quest Diagnostics)
90
Quest Diagnostics serum il-6 level testing
Sunitinib altered the liver metabolome. Principle component analysis (PCA) score plot (a) and scatter plot (b) derived from ultra‐performance LC electrospray ionization quadrupole time‐of‐flight MS data of liver ions. Each point represented an individual mouse liver sample (top) and an ion in the sample (bottom). Metabolites were labelled in the loading plot, which included three xenobiotic metabolites and seven endogenous metabolites. (c) Heatmap of 55 significantly changed endogenous metabolites (P < 0.05) in liver. (d) Correlation analysis between 55 changed endogenous metabolites and serum alkaline phosphatase (ALP) and hepatic Il1b <t>and</t> <t>Il6</t> mRNAs. All these metabolites showed a good correlation with serum ALP and hepatic Il1b, and Il6 mRNAs. (e) Real‐time PCR analysis was performed to measure the levels of mRNA‐encoding enzymes associated with fatty acid synthesis and metabolism. Acylcarnitine‐related genes were significantly inhibited after sunitinib treatment. (f) Real‐time PCR analysis of the hepatic mRNAs associated with bile acid synthesis and transport. Bile acid‐related genes were significantly inhibited after sunitinib treatment. Values represented fold change after normalization to control. All data plotted are means ± SEM (n = 5). *P < 0.05 significantly different from control. CA, cholic acid; Ile, isoleucine; Leu, leucine; LCA, lithocholic acid; LPC, lyso‐phosphocholine; LPE, lyso‐phosphatidylethanolamine; TCA, taurocholic acid; TDCA, taurodeoxycholic acid; TUDCA, tauroursodeoxycholic acid; TαMCA, tauro‐α‐muricholic acid; TβMCA, tauro‐β‐muricholic acid
Serum Il 6 Level Testing, supplied by Quest Diagnostics, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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serum il-6 levels  (Orient Bio Company)
90
Orient Bio Company serum il-6 levels
Sunitinib altered the liver metabolome. Principle component analysis (PCA) score plot (a) and scatter plot (b) derived from ultra‐performance LC electrospray ionization quadrupole time‐of‐flight MS data of liver ions. Each point represented an individual mouse liver sample (top) and an ion in the sample (bottom). Metabolites were labelled in the loading plot, which included three xenobiotic metabolites and seven endogenous metabolites. (c) Heatmap of 55 significantly changed endogenous metabolites (P < 0.05) in liver. (d) Correlation analysis between 55 changed endogenous metabolites and serum alkaline phosphatase (ALP) and hepatic Il1b <t>and</t> <t>Il6</t> mRNAs. All these metabolites showed a good correlation with serum ALP and hepatic Il1b, and Il6 mRNAs. (e) Real‐time PCR analysis was performed to measure the levels of mRNA‐encoding enzymes associated with fatty acid synthesis and metabolism. Acylcarnitine‐related genes were significantly inhibited after sunitinib treatment. (f) Real‐time PCR analysis of the hepatic mRNAs associated with bile acid synthesis and transport. Bile acid‐related genes were significantly inhibited after sunitinib treatment. Values represented fold change after normalization to control. All data plotted are means ± SEM (n = 5). *P < 0.05 significantly different from control. CA, cholic acid; Ile, isoleucine; Leu, leucine; LCA, lithocholic acid; LPC, lyso‐phosphocholine; LPE, lyso‐phosphatidylethanolamine; TCA, taurocholic acid; TDCA, taurodeoxycholic acid; TUDCA, tauroursodeoxycholic acid; TαMCA, tauro‐α‐muricholic acid; TβMCA, tauro‐β‐muricholic acid
Serum Il 6 Levels, supplied by Orient Bio Company, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/serum il-6 levels/product/Orient Bio Company
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il-6 serum levels  (Janssen)
90
Janssen il-6 serum levels
Sunitinib altered the liver metabolome. Principle component analysis (PCA) score plot (a) and scatter plot (b) derived from ultra‐performance LC electrospray ionization quadrupole time‐of‐flight MS data of liver ions. Each point represented an individual mouse liver sample (top) and an ion in the sample (bottom). Metabolites were labelled in the loading plot, which included three xenobiotic metabolites and seven endogenous metabolites. (c) Heatmap of 55 significantly changed endogenous metabolites (P < 0.05) in liver. (d) Correlation analysis between 55 changed endogenous metabolites and serum alkaline phosphatase (ALP) and hepatic Il1b <t>and</t> <t>Il6</t> mRNAs. All these metabolites showed a good correlation with serum ALP and hepatic Il1b, and Il6 mRNAs. (e) Real‐time PCR analysis was performed to measure the levels of mRNA‐encoding enzymes associated with fatty acid synthesis and metabolism. Acylcarnitine‐related genes were significantly inhibited after sunitinib treatment. (f) Real‐time PCR analysis of the hepatic mRNAs associated with bile acid synthesis and transport. Bile acid‐related genes were significantly inhibited after sunitinib treatment. Values represented fold change after normalization to control. All data plotted are means ± SEM (n = 5). *P < 0.05 significantly different from control. CA, cholic acid; Ile, isoleucine; Leu, leucine; LCA, lithocholic acid; LPC, lyso‐phosphocholine; LPE, lyso‐phosphatidylethanolamine; TCA, taurocholic acid; TDCA, taurodeoxycholic acid; TUDCA, tauroursodeoxycholic acid; TαMCA, tauro‐α‐muricholic acid; TβMCA, tauro‐β‐muricholic acid
Il 6 Serum Levels, supplied by Janssen, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Image Search Results


Sunitinib altered the liver metabolome. Principle component analysis (PCA) score plot (a) and scatter plot (b) derived from ultra‐performance LC electrospray ionization quadrupole time‐of‐flight MS data of liver ions. Each point represented an individual mouse liver sample (top) and an ion in the sample (bottom). Metabolites were labelled in the loading plot, which included three xenobiotic metabolites and seven endogenous metabolites. (c) Heatmap of 55 significantly changed endogenous metabolites (P < 0.05) in liver. (d) Correlation analysis between 55 changed endogenous metabolites and serum alkaline phosphatase (ALP) and hepatic Il1b and Il6 mRNAs. All these metabolites showed a good correlation with serum ALP and hepatic Il1b, and Il6 mRNAs. (e) Real‐time PCR analysis was performed to measure the levels of mRNA‐encoding enzymes associated with fatty acid synthesis and metabolism. Acylcarnitine‐related genes were significantly inhibited after sunitinib treatment. (f) Real‐time PCR analysis of the hepatic mRNAs associated with bile acid synthesis and transport. Bile acid‐related genes were significantly inhibited after sunitinib treatment. Values represented fold change after normalization to control. All data plotted are means ± SEM (n = 5). *P < 0.05 significantly different from control. CA, cholic acid; Ile, isoleucine; Leu, leucine; LCA, lithocholic acid; LPC, lyso‐phosphocholine; LPE, lyso‐phosphatidylethanolamine; TCA, taurocholic acid; TDCA, taurodeoxycholic acid; TUDCA, tauroursodeoxycholic acid; TαMCA, tauro‐α‐muricholic acid; TβMCA, tauro‐β‐muricholic acid

Journal: British Journal of Pharmacology

Article Title: Impaired clearance of sunitinib leads to metabolic disorders and hepatotoxicity

doi: 10.1111/bph.14664

Figure Lengend Snippet: Sunitinib altered the liver metabolome. Principle component analysis (PCA) score plot (a) and scatter plot (b) derived from ultra‐performance LC electrospray ionization quadrupole time‐of‐flight MS data of liver ions. Each point represented an individual mouse liver sample (top) and an ion in the sample (bottom). Metabolites were labelled in the loading plot, which included three xenobiotic metabolites and seven endogenous metabolites. (c) Heatmap of 55 significantly changed endogenous metabolites (P < 0.05) in liver. (d) Correlation analysis between 55 changed endogenous metabolites and serum alkaline phosphatase (ALP) and hepatic Il1b and Il6 mRNAs. All these metabolites showed a good correlation with serum ALP and hepatic Il1b, and Il6 mRNAs. (e) Real‐time PCR analysis was performed to measure the levels of mRNA‐encoding enzymes associated with fatty acid synthesis and metabolism. Acylcarnitine‐related genes were significantly inhibited after sunitinib treatment. (f) Real‐time PCR analysis of the hepatic mRNAs associated with bile acid synthesis and transport. Bile acid‐related genes were significantly inhibited after sunitinib treatment. Values represented fold change after normalization to control. All data plotted are means ± SEM (n = 5). *P < 0.05 significantly different from control. CA, cholic acid; Ile, isoleucine; Leu, leucine; LCA, lithocholic acid; LPC, lyso‐phosphocholine; LPE, lyso‐phosphatidylethanolamine; TCA, taurocholic acid; TDCA, taurodeoxycholic acid; TUDCA, tauroursodeoxycholic acid; TαMCA, tauro‐α‐muricholic acid; TβMCA, tauro‐β‐muricholic acid

Article Snippet: Serum IL‐6 levels were measured following the manufacturer's instructions (Cayman, Cat# 583371).

Techniques: Derivative Assay, Real-time Polymerase Chain Reaction, Control

Sunitinib induced liver injury in mice. (a) Haematoxylin and eosin staining of liver. Neutrophils were shown by yellow arrowheads in 60 and 150 mg·kg−1 sunitinib groups. Scattered haemocytes were shown by black arrowheads in 150 mg·kg−1 sunitinib groups. (b) Aspartate transaminase (AST), alanine transaminase (ALT), and alkaline phosphatase (ALP) enzymes activity in 0, 3, and 24 hr serum. (c) Real‐time PCR analysis of inflammatory factors in liver. Il1b, Il6, and Tnfa levels were significantly increased after 150 mg·kg−1 sunitinib treatment. Values represented fold change after normalization to control. (d) Western blot was used to measure IL‐1β and IL‐6. IL‐6 level was significantly increased after 60 and 150 mg·kg−1 sunitinib treatment. (e) Body weight was significantly decreased after 150 mg·kg−1 sunitinib treatment. All data plotted are means ± SEM (n = 5). *P < 0.05, significantly different as indicated

Journal: British Journal of Pharmacology

Article Title: Impaired clearance of sunitinib leads to metabolic disorders and hepatotoxicity

doi: 10.1111/bph.14664

Figure Lengend Snippet: Sunitinib induced liver injury in mice. (a) Haematoxylin and eosin staining of liver. Neutrophils were shown by yellow arrowheads in 60 and 150 mg·kg−1 sunitinib groups. Scattered haemocytes were shown by black arrowheads in 150 mg·kg−1 sunitinib groups. (b) Aspartate transaminase (AST), alanine transaminase (ALT), and alkaline phosphatase (ALP) enzymes activity in 0, 3, and 24 hr serum. (c) Real‐time PCR analysis of inflammatory factors in liver. Il1b, Il6, and Tnfa levels were significantly increased after 150 mg·kg−1 sunitinib treatment. Values represented fold change after normalization to control. (d) Western blot was used to measure IL‐1β and IL‐6. IL‐6 level was significantly increased after 60 and 150 mg·kg−1 sunitinib treatment. (e) Body weight was significantly decreased after 150 mg·kg−1 sunitinib treatment. All data plotted are means ± SEM (n = 5). *P < 0.05, significantly different as indicated

Article Snippet: Serum IL‐6 levels were measured following the manufacturer's instructions (Cayman, Cat# 583371).

Techniques: Staining, Activity Assay, Real-time Polymerase Chain Reaction, Control, Western Blot